Substance 6 was present to end up being the most selective PLK1 inhibitor over BRD4 inside our series (BRD4-BD1 IC50 = 2,579 nM, PLK1 IC50 = 9

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Substance 6 was present to end up being the most selective PLK1 inhibitor over BRD4 inside our series (BRD4-BD1 IC50 = 2,579 nM, PLK1 IC50 = 9.9 nM). 7.72 (1H, s), 7.41 C 7.31 (3H, m), 4.50 C 4.45 (1H, m), 4.31 C 4.24 (1H, q, = 6.7 Hz), 4.02 C 3.82 (6H, s, N-CH3 and O-CH3), 3.27 C 3.26 (6H, m), 3.22 (3H, s), 2.57 C 2.47 (6H, m), 2.06 C 1.86 (4H, m), 1.25 (3H, d, J = 6.6 Rabbit Polyclonal to E2AK3 Hz); 13C NMR (75 MHz, Compact disc3OD) 170.9, 166.6, 156.3, 153.0, 139.44, 138.7, 127.3, 121.2, 117.3, 117.3, 109.9, 59.5, 59.3, 56.4, 55.6, 55.02, 47.1, 44.9, 31.2, 30.5, 29.9, 28.5, 24.3, 23.8, 19.0; HRMS (ESI) m/z: (M+H)+ calcd for C27H37N7O3 536.3349, found 508.3031 (M+ +1). (8.54 (1H, d, = 8.4 Hz), 7.68 (1H, s), 7.59 (1H, s), 7.51 (1H, s), 7.42 (1H, s), 7.42 (1H, d, = 1.8 Hz), 4.56 C 4.46 (1H, m), 4.24 (1H, dd, = 8.0, 3.7Hz), 3.97 (3H, s), 3.31 (3H, s), 2.86 C 2.84 (2H, m), 2.31 (3H, s), 2.25 C 2.10 (4H, m), 2.07 C 2.04 (4H, m), 1.81 C 1.71 (14H, m), 1.37 C 1.21(4H, m), 0.87 (3H, t, = 7.3 Hz); 13C NMR (101 MHz, CDCl3) 163.9, 155.0, 152.1, 147.2, 137.9, 133.2, 126.2, 126.0, 118.8, 116.4, 115.8, 109.0, 58.8, 58.1, 54.4, 35.8, 32.4, 29.6, 29.1, 28.2, 23.5, 23.0, CBL0137 17.8, 13.9; HRMS (ESI) m/z: (M+H)+ calcd for C29H41N7O3 536.3349, found 536.3342 (M+ +1). (= 9.0 Hz), 7.74 (1H, s), 7.42 C 7.38 (3H, m), 4.21 C 4.17 (1H, m), 3.91 (3H, s), 3.87 C 3.83 (1H, m), 3.23 (3H, s), 2.91 C 2.88 (1H, m), 2.27 (3H, s), CBL0137 2.21 C 2.13 (2H, m), 2.02 C 1. 97 (2H, m), 1.92 C 1.83 (2H, m), 1.74 C 1.54 (8H, m), 1.41 C 1.36 (1H, m), 0.92 (3H, d, J = 6.3 Hz), 0.78 (3H, d, = 6.6 Hz); 13C NMR (75 MHz, Compact disc3OD) 169.1, 165.2, 156.2, 153.6, 148.4, 139.6, 134.0, 127.4, 121.2, 117.4, 117.3, 109.9, 59.6, 58.4, 56.4, 55.5, 45.8, 42.5, 32.0, 30.49, 30.4, 28.6, 25.7, 24.2, 23.9, 23.7, 21.7; HRMS (ESI) m/z: (M+H)+ calcd for C30H43N7O3 550.3506, found 550.3501 (M+ +1). (= 9.3 Hz), 7.69 (1H, s), 7.38 (3H, m), 3.99 C 3.90 (5H, m), 3.90 (3H, s), 2.72 C 2.65 (4H, m), 2.55 (3H, s), 1.86C1.76 (4H, m), 1.30 C 1.23 (9H, m); 13C NMR (75 MHz, Compact disc3OD) 169.2, 166.4, 156.3, 152.4, 148.3, 139.5, 134.1, 127.1, 121.3, 117.2, 109.8, 56.4, 54.7, 53.6, 46.6, 44.4, 30.7, 28.5, 21.5, 19.9; HRMS (ESI) m/z: (M+H)+ calcd for C25H35N7O3 482.2880, found 482.2884 (M+ +1). (= 9.0 Hz), 7.78 (1H, s), 7.45 C 7.42 (3H, m), 3.92 (3H, s), 3.56 C 3. 53 (2H, m), 3.22 (3H, s), 3.03 C 2.99 (2H, m), 2.37 (3H, m), 1.96 C 1.92 (3H, m), 1.70 C 1.65 (4H, m), 1.55 C 1. 38 (5H, m), 0.94 (3H, d, J = 6.3 Hz), 0.79 (3H, d, J = 6.6 Hz); 13C NMR (75 MHz, Compact disc3OD) 171.5, 171.4, 170.9, 169.1, 164.86, 153.0, 150.0, 140.1, 127.5, 121.2, 117.4, 110.0, 68.6, 68.5, 57.3, 56.4, 55.3, 55.2, 45.4, 43.4, 32.6, 31.6, 28.7, 25.8, 23.9, 21.7; HRMS (ESI) m/z: (M+H)+ calcd for C30H43N7O4 566.3455, found 566.3448 (M+ +1). (8.43 (1H, d, = 8.7 Hz), 7.75 (1H, s), 7.43 C 7.41 (3H, m), 4.31 C 4.29 (1H, q, J = 6.0 Hz), 3.94 (3H, s), 3.24 (3H, s), CBL0137 3.12C3.07 (3H, m), 2.90 C 2.87 (3H, m), 2.12 C 2.09 (3H, m), 1.91 C 1.89 (4H, m), 1.79 C 1.67 (6H, m), 1.26 (3H, d, CBL0137 = 6.9 Hz); 13C NMR (75 MHz, CBL0137 Compact disc3OD) 171.1, 169.1, 166.6, 156.2, 153.0, 148.3, 139.4, 134.0, 127.4, 121.2, 117.2, 109.9, 59.3, 56.4, 55.6, 55.4, 47.8, 45.7, 31.9, 30.5, 29.9, 28.5, 24.2, 23.8, 19.0; HRMS (ESI) m/z:.

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