Nevertheless, it appears that activation of the three isoforms of PPAR are involved in NO-mediated gastroprotection, as the shift in eNOS/iNOS expression and the reversion of glutathione peroxidase and reductase levels in the damaged stomach were not detected after comparative treatment with pioglitazone, a selective PPAR agonist (data not shown)

Nevertheless, it appears that activation of the three isoforms of PPAR are involved in NO-mediated gastroprotection, as the shift in eNOS/iNOS expression and the reversion…